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Conversely, the administration of Lactobacillus gasseri in rats subjected to an HFD can improve lipid sensing and reestablish appropriate bile acid signaling, indicating its potential therapeutic benefits 42

Patients who have undergone gastric bypass or other bariatric procedures have surgically altered anatomy that reduces the absorptive surface area in the stomach and small intestine

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Given a ~1hour half-life and hourslong systemic presence, a oncedaily or everyotherday regimen during any initial phase is typically pharmacokinetically reasonable